Immune cell composition in the endometrium of patients with a complete molar pregnancy: Effects on outcome

نویسندگان

چکیده

ObjectiveIn 15% of patients with complete hydatidiform mole (CHM), disease progresses to post-molar gestational trophoblastic neoplasia (GTN) after curettage. Tumor infiltrating lymphocytes (TILs) are essential in overcoming many tumors. Infiltrating lymphocyte composition and density may influence trophoblast regression development GTN. We analyzed immune cell curettaged endometrium CHM which spontaneously regressed, progressed GTN.MethodsSixteen spontaneous regression, 16 GTN were selected. Immune natural killer (NK) cells, T (NKT)-like Cytotoxic T-Regulatory T-Helper determined by multiplex immunohistochemistry (mIHC).ResultsCurettaged contained a slightly higher number cells compared NKT-like was significantly (483 ± 296 vs.295 143 (mean SD), p = 0.03) respectively. the group split ‘high’ ‘low’ (i.e. above below median cells). In high density, hCG normalized earlier than low (9.5 weeks, (range 3.7–14) vs. 12.9 8.6–17.9), 0.05).ConclusionA CHMs contribute molar cells.

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ژورنال

عنوان ژورنال: Gynecologic Oncology

سال: 2021

ISSN: ['1095-6859', '0090-8258']

DOI: https://doi.org/10.1016/j.ygyno.2020.11.005